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Metronidazole and sperm

Ligha , B. Bokolo and B. Abstract There is a growing concern about the decline in the quality of human sperm in recent years. Following reports by previous studies on the toxic effects of metronidazole on testicular functions, this study is designed to investigate further its direct effects on fertility potentials and that of the introduction of vitamin E and testosterone to metronidazole treated rats. The rats were randomly divided into a control and experimental groups. There were four major groups with 5 subgroups consisting of 5 rats each.
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Effect of metronidazole on fertility and testicular function in male rats.

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Metronidazole (Flagyl®) | MotherToBaby

This is called her background risk. This sheet talks about whether exposure to metronidazole may increase the risk for birth defects over that background risk. This information should not take the place of medical care and advice from your health care provider. Metronidazole met-roe-NYE-da-zole is an antibiotic used to treat infections. Metronidazole is commonly used to treat certain types of vaginal infections. It is available in oral, rectal, topical, vaginal and intravenous I.
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The reproductive toxicology of metronidazole was studied in rats. After 2 and 4 weeks of metronidazole treatment, mating performance and fertility in treated and control animals were comparable. After 6 weeks of treatment, all high-dose rats were infertile; however, fertility in low- and middose rats was not affected. High-dose male rats killed after 8 weeks of treatment showed markedly decreased testicular and epididymal weights, and markedly decreased testicular spermatid counts and epididymal sperm counts.
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